Quentin Liu Selected Research

Aurora Kinase A

1/2022	Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4.
1/2022	A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells.
1/2021	Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
1/2021	Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer.
1/2021	CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer.
11/2020	Aurora kinase inhibitor restrains STAT5-activated leukemic cell proliferation by inducing mitochondrial impairment.
9/2020	A Novel Aurora Kinase Inhibitor Attenuates Leukemic Cell Proliferation Induced by Mesenchymal Stem Cells.
1/2019	Aurora kinase A stabilizes FOXM1 to enhance paclitaxel resistance in triple-negative breast cancer.
1/2019	Activation of Aurora A kinase increases YAP stability via blockage of autophagy.
9/2018	Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors.

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Quentin Liu Research Topics

Disease

82	Neoplasms (Cancer) 11/2022 - 05/2008
22	Breast Neoplasms (Breast Cancer) 05/2022 - 11/2010
15	Nasopharyngeal Carcinoma 01/2022 - 05/2008
14	Carcinogenesis 01/2022 - 10/2008
12	Lung Neoplasms (Lung Cancer) 01/2022 - 07/2014
10	Neoplasm Metastasis (Metastasis) 01/2021 - 04/2010
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 03/2008
9	Leukemia 11/2020 - 03/2008
6	Stomach Neoplasms (Stomach Cancer) 12/2018 - 02/2009
5	Triple Negative Breast Neoplasms 11/2022 - 01/2016
5	Adenocarcinoma 07/2020 - 01/2013
5	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2016 - 03/2014
4	Polyploidy 11/2016 - 11/2013
3	Disease Progression 03/2021 - 03/2013
3	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 02/2013
3	Carcinoma (Carcinomatosis) 05/2016 - 05/2008
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2021 - 01/2020
2	Squamous Cell Carcinoma of Head and Neck 07/2020 - 07/2008
2	Thyroid Neoplasms (Thyroid Cancer) 11/2018 - 08/2018
2	Anaplastic Thyroid Carcinoma 08/2018 - 07/2018
2	Infections 07/2018 - 07/2014
2	Hepatocellular Carcinoma (Hepatoma) 01/2017 - 11/2016
2	Epilepsy (Aura) 11/2016 - 08/2014
2	Lymphatic Metastasis 01/2016 - 07/2014
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2014 - 01/2013
2	Acute Promyelocytic Leukemia 01/2014 - 05/2011
2	Aneuploidy (Aneuploid) 07/2008 - 05/2008
1	Alzheimer Disease (Alzheimer's Disease) 06/2022
1	Bites and Stings (Sting) 01/2022
1	Endometrial Neoplasms (Endometrial Cancer) 11/2021
1	Prostatic Neoplasms (Prostate Cancer) 01/2021

Drug/Important Bio-Agent (IBA)

19	Aurora Kinase AIBA 01/2022 - 08/2009
13	Phosphotransferases (Kinase)IBA 01/2022 - 11/2007
13	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2011
11	Aurora KinasesIBA 05/2022 - 03/2008
9	Biomarkers (Surrogate Marker)IBA 03/2019 - 09/2011
7	Pharmaceutical PreparationsIBA 01/2021 - 07/2014
6	Beclin-1IBA 01/2016 - 04/2010
6	tozasertibIBA 11/2013 - 03/2008
5	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2018
4	Biological ProductsIBA 11/2021 - 01/2016
4	CateninsIBA 01/2021 - 11/2014
4	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2018
4	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2016
4	Imatinib Mesylate (Gleevec)FDA Link 11/2016 - 10/2014
4	Sirolimus (Rapamycin)FDA Link 05/2016 - 11/2013
3	Messenger RNA (mRNA)IBA 01/2021 - 10/2016
3	Caspase 3 (Caspase-3)IBA 07/2018 - 05/2008
3	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 07/2014
3	AKI603IBA 11/2016 - 08/2014
3	Carrier Proteins (Binding Protein)IBA 10/2016 - 09/2011
3	Histones (Histone)IBA 07/2016 - 05/2008
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2016 - 04/2015
3	4- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazolineIBA 08/2015 - 05/2008
3	Cadherins (E-Cadherin)IBA 03/2015 - 10/2008
2	Immune Checkpoint InhibitorsIBA 11/2022 - 01/2020
2	Protein Isoforms (Isoforms)IBA 01/2022 - 12/2018
2	6-methyladenineIBA 01/2022 - 01/2021
2	Histone Deacetylase InhibitorsIBA 01/2021 - 01/2014
2	MLN 8237IBA 01/2021 - 01/2021
2	RetinoidsIBA 01/2020 - 05/2011
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 07/2014
2	RNA Splicing FactorsIBA 12/2018 - 09/2014
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/2018 - 01/2017
2	VimentinIBA 10/2017 - 03/2015
2	CaspasesIBA 11/2016 - 05/2016
2	Small Interfering RNA (siRNA)IBA 04/2016 - 04/2015
2	Autophagy-Related ProteinsIBA 01/2016 - 03/2012
2	ChromatinIBA 01/2016 - 10/2014
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2010 - 11/2009
1	Monomeric GTP-Binding ProteinsIBA 06/2022
1	snake venom protein C activatorIBA 01/2022
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2022
1	InterferonsIBA 01/2022
1	IronIBA 11/2021
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2021
1	Nortriptyline (Aventyl)FDA LinkGeneric 11/2021
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2021
1	Trastuzumab (Herceptin)FDA Link 03/2021
1	Arginine (L-Arginine)FDA Link 01/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Therapeutic UsesIBA 01/2021
1	Exportin 1 ProteinIBA 01/2021
1	LigandsIBA 01/2021
1	3- (1H- indazol- 5- yl)- N- propylimidazo(1,2- b)pyridazin- 6- amineIBA 01/2021
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2021
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2021
1	Ribonuclease III (RNase III)IBA 01/2021
1	N-methyladenosineIBA 01/2021
1	Gefitinib (Iressa)FDA Link 01/2021
1	STAT5 Transcription FactorIBA 11/2020
1	CytokinesIBA 09/2020

Therapy/Procedure

40	Therapeutics 01/2022 - 08/2008
11	Drug Therapy (Chemotherapy) 01/2021 - 11/2009
5	Immunotherapy 11/2022 - 01/2020
5	Radiotherapy 11/2021 - 08/2018
2	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2021 - 11/2015
2	Chemoradiotherapy 05/2020 - 11/2019
2	Transplantation 08/2016 - 11/2011